The return leg will be played at Ajax's Johan Cruyff Arena on May 8.
Two goals from Marcos Alonso gave Chelsea a 2-1 victory over Tottenham Hotspur on Sunday in the first-ever Premier League game at Wembley Stadium.
Liverpool resumed their march to a second Premier League title on Sunday with a 2-1 victory over West Ham United.
Villa remain fourth on 56 points, three points above Spurs in fifth, having played a game more. West Ham are seventh on 44, three points behind sixth-placed Manchester United who have a game in hand.
English Premier League club Sunderland have appointed Gustavo Poyet as manager on Tuesday. The 45 year-old has agreed a two year contract at the Stadium of Light and will take charge of the Black Cats with immediate effect.
Liverpool reclaimed top spot in the Premier League with a 3-1 win over Burnley at Anfield on Saturday, but they were made to battle hard by a brave visiting side.
Manchester United were denied by a spirited Stoke City performance as Joe Allen pounced late to secure the visitors their first point at Old Trafford since 1989 in a deserved 1-1 Premier League draw.
IMAGES from the Europa League matches played on Thursday
Manchester City celebrated their Premier League title on Sunday, beating Chelsea 1-0 with an early goal by Julian Alvarez in the team's home finale at a sun-drenched Etihad Stadium.
IMAGES from the English Premier League matches played on Sunday.
A summary of Thursday's action in the Premier League.
Tottenham Hotspur have reached agreement with the FA to host Champions League games at Wembley next season with an option to use the national stadium for all matches in the 2017-18 campaign while they are building a new ground. "Having Tottenham at Wembley for big European nights next season is a welcome opportunity for us to further the stadium's position as a world-class venue," FA chief executive Martin Glenn said in a joint statement with Spurs on Saturday. Tottenham are redeveloping White Hart Lane by building a 400 million pounds ($584.92 million) 61,000-seater stadium next to their existing ground and will have a reduced capacity next term as a result. They will use Wembley to meet UEFA requirements. "Given the current reduction in capacity at White Hart Lane for next season and the ticketing requirements for (the) Champions League, playing at Wembley will mean that we can continue to accommodate all of our existing season ticket holders," Tottenham chairman Daniel Levy said.
IMAGES from the Premier League matches played on Saturday.
A round-up of Saturday's action in the English Premier League.
Leandro Trossard transformed the mood at Arsenal with the winning goal as they recovered from an early setback to beat Tottenham Hotspur 2-1 at home.
Rashford put United ahead in the seventh minute
Beyond the handball incident, the Belgian champions were the better side on the night. Villa's World Cup-winning keeper Martinez was pressed into action early by Brugge, who had seven shots on target to the Premier League club's one, and made several key saves to keep his team in the game.
IMAGES from the EPL matches played on Saturday.
Arsenal moved up to second in the Premier League and within six points of Liverpool after a largely trouble-free, if slightly pedestrian, 1-0 win at home to struggling Ipswich Town on a chilly night in north London on Friday.
IMAGES from the English Premier League matches played on Saturday.
Thierry Henry salvaged a 1-1 draw for Arsenal against Tottenham Hotspur in a final north London derby
The 58-year-old pointed to the 26-point gap in the Premier League table between runners-up Liverpool and his fourth-placed former team as evidence of a massive gulf between the sides.
Tottenham Hotspur's England duo Harry Kane and Dele Alli fired them to a comfortable 2-0 win over mid-table Watford that cemented their place in the top four at Wembley on Monday.
Mourinho's side failed to turn their domination into more goals and things got edgy late on when Saville's shot evaded Gazzaniga who seemed slow to get down.
Llorente's second-half treble, a double from Son Heung-min and a late effort from Kyle Walker-Peters in driving snow at a freezing Wembley Stadium settled an game where tensions had threatened to bubble over before the break.
IMAGES from the EPL matches played on Sunday.
A summary of Saturday's action in the FA Cup third round.
Seven-time European champions AC Milan hit back from two goals down against Celtic to claim a 4-2 victory that sent them into the Europa League knockout phase on Thursday as they were among 14 teams to progress in Europe's second-tier competition.
A last-minute own goal gave Liverpool a 2-1 win over Tottenham Hotspur to keep them top of the Premier League but Manchester City stayed two points behind having won at Fulham. Huddersfield Town were relegated after their defeat by Crystal Palace.
Images from the English Premier League matches played on Saturday, April 13.
Fourth-tier Newport County stunned former FA Cup winners Leeds United with a last-gasp 2-1 win in the third round to spark a joyous pitch invasion at their Rodney Parade ground on Sunday.
Images from Sunday's action in the English Premier League.
Manchester City climbed back into the Premier League's top four as second-half goals by Phil Foden, Julian Alvarez and Bernardo Silva sealed a comeback 3-1 victory at Everton on Wednesday.
Images from Sunday's action in the Premier League.
There is still a long way to go, with a young Ajax side sure to present a formidable obstacle to a Spurs squad shorn of leading strikers Harry Kane and Son Heung-min.
Arsenal ruthlessly exploited Emmanuel Adebayor's moment of madness to come from behind and beat Tottenham Hotspur 5-2 in another eventful north London derby.
Arsenal needed a late equaliser from Theo Walcott to salvage a 1-1 draw against arch-rivals Tottenham Hotspur in the League Cup semi-final.
The Copa del Rey semi-final draw will be made on Friday.
Arsenal goalkeeper Petr Cech will be out for three to four weeks with the calf injury he picked up in Wednesday's Premier League defeat by Swansea City, manager Arsene Wenger has said.
A summary of Sunday's action in the Premier League.
